Endocrine Abstracts

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

In clinical trials, the SGLT2 inhibitor Canagliflozin inhibits renal reabsorption of glucose, increases its excretion and reduces hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). The increase in glucosuria and diuresis produced, results in a reduction in weight and blood pressure (BP). Moreover, It may cause genital and urinary tract infections. However, does Canagliflozin behave in the same way in routine clinical practice?Objective: To ...

Introduction: Acute pancreatitis induced by hypertriglyceridemia is a severe condition and its management is complicated.Case report: We present a case of severe acute pancreatitis induced by hypertriglyceridemia secondary to lipoprotein lipase -LPL- deficiency (188 Gly-Glu mutation, LPL undetectable activity) in a pregnant patient with gestational diabetes.The patient was sent to our Lipid Unit in the 13th gestation’ week. Th...

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study vitamin D deficiency prevalence in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 88 morbidly obese patients befor...

Objective: To determine the characteristics of patients with familiar hypercholesterolemia studied in a specific unit of lipids.Material and methods: A descriptive study of patients followed in our unit over the last 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH).Results: Data from 111 patients were analyzed: 66 with HFH and 45 with FCH.Featu...

Aim: To analyze the influence of bariatric surgery over serum lipids in patients with morbid obesity after 1 year of surgery.Methods: Retrospective study of 88 patients before and after 1 year of bariatric surgery (65 by pass and 23 sleeve). We collected data about age, sex, other diseases, anthropometric measures and biochemical parameters: glucose, uric acid, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), VLDL and non-HDL-C, homocistein and ...

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to various factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study the prevalence of vitamin D deficiency in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 72 morbidly obese...

Introduction: Research has demonstrated that knowledge about medications, diet, exercise, home glucose monitoring, foot care, and treatment modifications is necessary to effectively self-manage diabetes, and the assessment of diabetes-related knowledge is an important first step from which to individualize diabetes education programs and make evaluations of their effectiveness.Purpose: To assess the knowledge of diabetes mellitus (about the disease, its ...

Introduction: A key factor in the progressive increase in the prevalence of obesity is poor dietary habits. The treatment of obesity with regular diets often fail, so knowing the specific habits of these patients can be very useful to individualize treatment.Objective: Evaluate the dietary habits of subjects consulting for obesity in our clinic of Endocrinology and NutritionMaterials and methods: We conducted a survey of eating hab...